If your skin starts flaking during GLP-1 treatment, review the cleanser, moisturizer and active ingredients you already use before buying another serum.
Change the shower routine
AAD recommends a five-to-ten-minute bath or shower in warm water, a gentle cleanser, and patting rather than rubbing with a towel. Apply moisturizer while skin remains damp. [2]
Check the label, not the scent
For dry skin, AAD favors cream or ointment over lotion and recommends fragrance-free products. An unscented label can mean that ingredients mask an odor; those ingredients may still irritate sensitive skin. [2]
AAD's GLP-1 guidance also recommends moisturizing the body and cuticles, not only the face. [1]
Review the retinoid
AAD warns that retinoids may irritate and cause flaking when skin becomes dry during GLP-1 treatment. If a retinoid is part of a prescribed treatment, ask the prescriber how to adapt it to your current symptoms. [1]
Bring the product name and strength to the appointment. Note when you started it, when flaking began and where you apply it. That record helps you describe the sequence without assuming the injection caused every change.
When home care is insufficient
AAD says effective self-care for dry skin tends to show improvement within two weeks. That is general guidance, not a GLP-1 recovery deadline. Persistent or worsening dryness can have other causes, including a skin condition or medication, and warrants a dermatologist's assessment. [3]
If moisturizer burns or stings, tell your dermatologist. Ask before adding an anti-itch cream: AAD notes that some products can aggravate very dry skin. [2]
If your concern is reduced facial fullness rather than flaking, see our article on facial changes and the limits of firming creams.
This article provides general education, not a diagnosis or an individual treatment plan. Medication information refers to US sources. Discuss medication, nutrition and cosmetic treatment decisions with qualified clinicians.
Sources
- How can GLP-1 drugs affect my skin, hair, and nails? Updated February 17, 2026American Academy of Dermatology
- Dermatologists' top tips for relieving dry skin, updated January 2, 2026American Academy of Dermatology
- Dry skin: OverviewAmerican Academy of Dermatology